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Postmaturity is defined as a pregnancy that exceeds 42 complete weeks (292 days from the first day of the last period. Where possible, first trimester ultrasound rather than LMP dating should be relied on to assess pregnancy duration.

Associated Risks
• Beyond around 41 weeks placental function may decline and become insufficient, reducing the supply of oxygen and nutrients to the fetus. Placental insufficiency increases the risk of intrapartum fetal hypoxia.
• There is also increased risk of meconium aspiration syndrome and neonatal hypoglycaemia.
• The risk of stillbirth or neonatal death (in healthy women with normal pregnancies) is 3 times greater at 42 weeks than 37 weeks. The risk is 6 times greater at 43 weeks.
• The risk of caesarean delivery and maternal complications also increase with gestational age.
• There is increased risk of fetal macrosomia i.e. birth weight >4 kg and birth injury.
• Some fetal anomalies e.g. anencephaly, are associated with prolonged pregnancy.
• Increased risk ofepilepsy in the neonate, particularly if delivered by instrumental delivery or caesarean section.^07-01
Epidemiology

Approximately 7.5% of pregnancies continue to 42 weeks or beyond.⁰⁶⁰²Post-maturity is a syndrome seen in some infants born at or after 42 weeks. However, the term post-mature is often used to describe any infant born after 42 weeks.

Risk Factors

Previous prolonged pregnancy increases risk of recurrence in subsequent pregnancies 2-3 fold.⁹⁹⁰¹
Few pre-natal risk factors are known. However recent work suggests an association with:

• BMI >35⁰⁶⁰¹
• Primigravidity
• Fish consumption in first 2 trimesters⁰⁶⁰³
Presentation

Symptoms

• When post-mature the neonate has lower than normal amounts of subcutaneous fat and reduced mass of soft tissue.
• The skin may be loose, flaky and dry.
• Fingernails and toenails may be longer than usual and stained yellow from meconium.

Signs

• Before delivery there may be reduced fetal movement.
• A reduced volume of amniotic fluid may cause a reduction in the size of the uterus.
• Meconium stained amniotic fluid may be seen when the membranes have ruptured.
Investigations

Women with no other indications for induction, who do not wish labour to be induced can be offered monitoring to assess placental function and fetal health. There is a lack of evidence with which to assess the benefits of monitoring and the effectiveness of the various techniques.⁰⁵⁰¹ Management

Management of prolonged pregnancy in the absence of other complications is controversial.

• The Royal College of Obstetricians and Gynecologists guidelines recommend that women should be offered induction after 41 weeks.
• NNT to avoid 1 fetal or neonatal death is high but decreases constantly with gestational age beyond 41 weeks.0801
• Women who decline induction should be offered increased antenatal monitoring from 42 weeks, consisting of twice-weekly cardiotocography (CTG) and ultrasound estimation of single deepest amniotic pool. A pool depth of <8cm indicates increased intrapartum risk to the fetus.⁰⁷⁰²
• If expectant management some sources recommend labour should be induced at the beginning of the 43rd week.⁰⁵⁰¹

However in a recent randomised trial there were no differences between induced (at 289 days) and monitored groups (every 3 days) in neonatal morbidity, mode of delivery, and general outcome.

Practices for managing pregnancies continuing beyond term differ in Europe and raise questions about the health and other impacts in countries with markedly high or low postterm rates.⁰⁷⁰⁴

 






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This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.

I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.














 

Thank you for choosing to visit us.




This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.

I do hope that you find the answers to your women's health questions in the patient information and medical advice provided. If you still have unanswered questions, please consider entering them into one of our forums and I will try to assist you.  







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