Chemistry of Danazol
Danazol is a derivative of the synthetic hormone preparation that is related to testosterone. It has weak androgenic activity and no estrogenic or progestagenic effects.
The danazol molecule.
Side Effects of Danazol
side effects include nausea, rashes, headache, visual disturbance, acne
weight gain and an increase in body hair but these are more common at high dose levels of 600 or 800mg daily.
Should any of these side effects occur, they usually rapidly
disappear when the danazol is discontinued. In practice,
danazol tends to be used when other medications are unsuccessful. Many patients have no problems with
danazol, particularly when it is used in low dosage, and it often improves symptoms.
Danazol tends to reduce the hormone fluctuations. Danazol 400mg daily will generally suppress the menstrual cycle and can be effective in PMS. Occasionally it may be effective at lower dose levels whilst some patients will need more.
Danazol can have adverse effect on a fetus so that ade quate contraception is essential.
As danazol may cause some degree of fluid retention, conditions that might be influenced by this factor, such as epilepsy, migraine, or cardiac or renal dysfunction, require careful observation.
Contraindications to danazol
Danazol is contraindicated in pregnancy because it
could masculinise a female fetus. Danazol is also
contraindicated when breast feeding.
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