Am J Obstet Gynecol. 1981 Nov 15;141(6):723-7.
Danazol: endocrine consequences in healthy women.
Luciano AA, Hauser KS, Chapler FK, Sherman BM.
We studied the effects of danazol on pituitary and gonadal function in seven normal women who volunteered to take danazol, 400 mg twice daily, for 2 months. We measured circulating levels of sex steroids, gonadotropins, and prolactin on alternate days throughout a control menstrual cycle and during treatment. Danazol inhibited ovulation in all subjects. The amenorrheic state induced by danazol was characterized by normal basal levels of gonadotropins, prolactin, and estrogen. Serum androgen levels were significantly increased as was the urinary excretion of 17-ketosteroids. The LH and FSH responses to gonadotropin-releasing hormone were enhanced during treatment, and there was a normal LH rise following administration of estradiol valerate, indicative of intact positive feedback. These observations fail to support the contention that danazol suppresses pituitary gonadotropin secretion or directly inhibits steroidogenesis. The results suggest that danazol may have a primary site of action at the ovary by suppressing the normal, orderly process of follicular maturation.
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- 1 What might I need to know about drugs frequently used in gynaecology?
- 2 How do hormone treatments work?
- 3 In what situations may hormone treatments be indicated?
- 4 What are the sources of hormone treatments?
- 5 What determines the effect of a hormone treatment?
- 6 When are hormones used in combination?
- 7 Why do hormone treatments sometimes cause side effects?
- 8 When are oestrogens prescribed?
- 9 What are the possible side effects and risks of oestrogen therapy?
- 10 When are progestogens prescribed?
- 11 What are the possible side effects and risks of progestogen therapy?
- 12 How is the relative potency (strength) of progestogens measured?
- 13 When is danazol prescribed?
- 14 When are androgens prescribed?
- 15 What are the possible side effects of androgens?
- 16 What are gonadotrophin releasing hormone analogues and gonadotrophins?
- 17 When are GnRH analogues prescribed?
- 18 What are anti-hormones?
- 19 By which routes can drugs be given and why are they chosen?
- 20 Why do I seem to be given a medication with a different name but my doctor says it is the same as before?
- 21 I am worried about the possible side effects of a medication. What should I do?
- 22 How are new treatments developed?
- 23 What is a meta-analysis?
- 24 What is meant by the term evidence based medicine information?
- 25 What is a clinical trial?
- 26 What is a placebo?
- 27 What is meant by relative risk?
- 28 What is informed consent?
- 29 What is the current opinion of the medical profession on alternative or complementary medicine?
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