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Am J Obstet Gynecol. 1981 Nov 15;141(6):723-7.
Danazol: endocrine consequences in healthy women.
Luciano AA, Hauser KS, Chapler FK, Sherman BM.
We studied the effects of danazol on pituitary and
gonadal function in seven normal women who volunteered
to take danazol, 400 mg twice daily, for 2 months. We
measured circulating levels of sex steroids,
gonadotropins, and prolactin on alternate days
throughout a control menstrual cycle and during
treatment. Danazol inhibited ovulation in all subjects.
The amenorrheic state induced by danazol was
characterized by normal basal levels of gonadotropins,
prolactin, and estrogen. Serum androgen levels were
significantly increased as was the urinary excretion of
17-ketosteroids. The LH and FSH responses to
gonadotropin-releasing hormone were enhanced during
treatment, and there was a normal LH rise following
administration of estradiol valerate, indicative of
intact positive feedback. These observations fail to
support the contention that danazol suppresses pituitary
gonadotropin secretion or directly inhibits
steroidogenesis. The results suggest that danazol may
have a primary site of action at the ovary by
suppressing the normal, orderly process of follicular
maturation.
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