When are gonadotrophin releasing hormone analogues (GNRH) prescribed?
An anti-hormone (hormone antagonist) blocks the action of a hormone on receptor sites. They are receiving increasing attention in a variety of treatments. The anti-oestrogens, clomifene and tamoxifen, are used in infertility (clomiphene citrate) and tamoxifen is also widely used for patients with breast cancer (Q32.42). The anti-androgen, cyproterone, competes with androgens and is used in the management of hirsutism (Q8.15). Spironolactone is an aldosterone antagonist which has been used mainly to increase urine production but it also has anti-androgenic activity.
Mifepristone is a synthetic anti-progesterone. It is licensed as an abortifactant (an agent used to procure miscarriage) up to 63 days gestation(Q19.10)
Gonadotrophin releasing hormone analogues block GnRH from the hypothalamus acting on the pituitary gland so that FSH and LH levels and consequently oestrogen levels fall (Q33.17).
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