• Down-regulation is employed in IVF protocols (Q10.24) to ensure that there is no natural release of LH which could result in premature and unplanned release of eggs from the ovaries.
  • Suppression of gonadotrophins by GnRH analogues is beneficial for pre-operative preparation for fibroid removal (17)
  • and in the management of endometriosis (endometriosis).
  • When administered in intermittent bolus by a pump, GnRH agonists are effective in inducing ovulation.

A new generation of GnRH antagonists is being produced and they are currently under investigation.

  • These antagonists have only inhibitory effects so that they will not cause a flare response (Q33.5).





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 Women's Health