The significance of breast cancer in the family on the chance of another family member being affected is disputed. Early studies found the risk ratio (Q33.27) for developing breast cancer to be 1.9 if the mother has had cancer of the breast and 2.3 if the disease had affected a sister. There is virtually no increased risk for more distant relatives. However, a meta-analysis (Q33.23) could find no evidence that there as an increased risk of breast cancer even if a close relative had the disease. A meta-analysis of 51 studies, reported in The Lancet in 1997 evaluating the relationship between HRT and breast cancer demonstrated no increased risk for those whose mothers or sisters have had breast cancer to those with no family history.


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 Women's Health