J Clin Oncol. 2006 Mar 20;24(9):1454-8.

Pretreatment CA-125 and risk of relapse in advanced ovarian cancer.

Markman M,Liu PY,Rothenberg ML,Monk BJ,Brady M,Alberts DS.

M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA. mmarkman@mdanderson.org

Purpose:

A previous report suggested the nadir serum CA-125 level within the group of patients with ovarian cancer who achieved normalization of CA-125 accurately defined the risk of relapse. Using similar CA-125 subgroups, we sought to determine if the baseline CA-125 level before initiation of maintenance chemotherapy in women achieving a clinically-defined complete response to primary chemotherapy would be of prognostic value.

Patients and

Methods:

Patients included in this retrospective analysis had been treated on one of two previously reported trials of maintenance chemotherapy (three v 12-monthly cycles of paclitaxel; oral altretamine), with a baseline CA-125 level of< or = 35 u/mL. Progression-free survival (PFS) from study entry was analyzed by the Cox regression model.

Results:

The distribution of premaintenance baseline CA-125 levels for the 384 patients was 58%, 34%, and 8% for values of (A)< or = 10 u/mL, (B) 11 to 20 u/mL, and (C) 21 to 35 u/mL, respectively. The baseline CA-125 was highly statistically significant, either as a categoric variable (P< .001) or as a continuous variable (P< .0001). Median PFS was 24 months, 17 months, and 7 months for groups (A), (B), and (C), respectively. There was no evidence the CA-125 effect differed by trial or treatment in an interaction analysis (P = .70).

Conclusion:

The baseline CA-125 level before initiation of maintenance chemotherapy strongly predicts the risk of subsequent relapse. Patients with premaintenance baseline CA-125 values< or = 10 u/mL have a superior PFS compared with higher levels in the normal CA-125 range.

Women's Health



women's health


Back Home Up Next -checksum="7918" ends

Please click on the required question.



Your Own Web Presence

 

For £35

 

 

FirstWebSiteDesign.com

 

Have your own web ad on the internet and optimized for good positioning.

 

Your Own Dedicated Web Page Designed Specifically For You

 

More Effective

Than Your Own

Single Page Website

 

For £35

 

 

FirstWebSiteDesign.com