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In Vivo. 2004 Nov-Dec;18(6):831-6

Serum CA 125 combined with transvaginal ultrasonography for ovarian cancer screening.

Authors:

Roupa Z,Faros E,Raftopoulos V,TzavelasG,Kotrotsiou E,Sotiropoulou P,Karanikola E,Skifta E,Ardavanis A.

Department of Nursing, Faculty of Health Care Sciences, High Technological Education Institute, Larissa, Greece. zoeroupa@yahoo.gr

Background:

The aim of this study was to evaluate the combination of serum CA125 and Transvaginal Ultra Sonography (TVUS) score, as a screening procedure for ovarian cancer in premenopausal and postmenopausal women. PATIENTS AND

Methods:

A retrospective case-control pilot study was conducted. The files of 120 women with ovarian neoplasia detected by TVUS and increased CA125 level, within the framework of a prevention program, were reviewed. The relationship between the above tests and epithelial malignancy was investigated using the SPSS-12 program for Windows.

Results:

The combination of CA125 value exceeding 30U/ml and a TVUS score > or = 35 had a sensitivity of 81.7% and specificity of 100% in predicting ovarian cancer. Mathematical analysis of the logistic model of our variables revealed a mathematical model that can calculate the likelihood of ovarian cancer detection, by using a combination of CA125 > or = 30U/ml and TVUS score > or = 35.

Conclusion:

By combining TVUS and CA125, an accurate prediction for the presence of ovarian cancer may be achieved. Further investigation in a larger population is warranted.