Transdermal natural progesterone cream for
postmenopausal women: inconsistent data and
complex pharmacokinetics.
Elshafie MA, Ewies AA.
Faculty of Health Wellbeing and Science University
Campus of Suffolk, UK.
Transdermal progesterone cream (PC) is
propagated as a possible alternative to hormone
replacement therapy (HRT) in the management of
menopausal symptoms and treatment of
osteoporosis. Nonetheless, considerable concerns
were raised regarding the inconsistent results
and the credibility of some studies that were
not peer-reviewed. Further, the complex nature
and diversity of the pharmacokinetics of
progesterone led to difficult interpretation of
the findings. Given the current best available
evidence, using PC for postmenopausal therapy
regimens should be considered as an
unsubstantiated treatment option, and its
clinical applications must be restricted to
well-designed interventional trials that assess
its efficacy and safety.
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