Tibolone is a synthetic steroid that has progestogenic and some androgenic properties (Q 2.9) as well as oestrogenic effects. As it has effects of all three groups of hormones produced by the ovaries (the female gonads) it has been called gonadomimetic. Livial has the advantages of HRT whilst allowing bleed-free HRT for postmenopausal women. There may be irregular bleeding for up to 4-6 months in 10% of patients.
As tibolone has some androgenic effects, from a theoretical point of view it might be expected to improve sexual function and there is some clinical evidence to support this.
There is evidence that Tibolone is less prone to cause irregular bleeding than low dose continuous combined HRT.0701
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