HRT Hormone Replacement Therapy
HRT Hormone Replacement Therapy


What is tibolone (Livial)?

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Gynecol Endocrinol. 2005 Apr;20(4):209-12.

Effect on sexual life--a comparison between tibolone and continuous combined conjugated e quine estrogens and medroxyprogesterone acetate.

Authors:

Uygur D,Yesildaglar N,Erkaya S.

Zubeyde Hanim Maternity Hospital, Telsizler, Ankara, Turkey. uygurdc@superonline.com

Objectives:

To compare the effects of tibolone 2.5 mg with those of continuous combined conjugated e quine estrogens 0.625 mg/day and medroxyprogesterone acetate 5 mg/day (CEE/MPA) on sexual life in postmenopausal women.

Methods:

Eighty women were randomized to treatment with either tibolone or continuous combined CEE/MPA. Subjects were asked about sexual desire, sexual excitement, sexual arousal, orgasm capacity, vaginal lubrication during sexual activity and dyspareunia before and after the treatment.

Results:

After 6 months of treatment, a total of 72 women completed the study. When tibolone was compared with continuous combined CEE/MPA, significantly higher scores were found for the items assessing sexual desire, sexual excitement, intercourse Frequency and vaginal dryness (p< 0.05).

Conclusion:

This study indicates that both tibolone and continuous combined CEE/MPA treatment were associated with significant improvements in sexual function in postmenopausal women. However, tibolone treatment improved sexual function to a greater extent than continuous combined CEE/MPA.


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