I have fibroids. Can I take HRT?

Osman Temiz Mahallesi, 1. cad 1. sok. Pinar Apt. 4/7,Dikmen Ankara 06450; Turkey.

Title:

The effects of hormone replacement therapy on uterine fibroids in postmenopausal women (1996-1175).

Source:

Abstract:

Objectives:

To evaluate and compare the effects of two different modalities of hormone replacement therapy (HRT) on the size of uterine fibroids.

Design:

Setting:

Patients:

Postmenopausal women with small asymptomatic uterine fibroids were selected.

Interventions:

One group was treated with 50 mug transdermal E2 plus 5 mg medroxyprogesterone acetate (MPA) continuously, whereas the second group was given 0.625 mg conjugated e quine estrogen plus 2.5 mg MPA continuously.

Main Outcome Measure:

The size of the uterine fibroids was measured before and after the first year of HRT.

Results:

At the end of the first year on HRT, the size of the uterine fibroids was re- evaluated sonographically and no significant difference was found with the oral group, whereas there was a significant increase in the transdermal group.

Conclusion:

Hormone replacement therapy with 50 mug transdermal E2 plus 5 mg MPA increases the size of the uterine fibroids.

Q 27. 1 HRT help me with the psychological difficulties that I am experiencing around?
Q 27. 2 HRT help my mental ability?
Q 27. 3 Can HRT reduce my chance of developing heart disease?
Q 27. 4 How does HRT protect against coronary heart disease?
Q 27. 5 If I am at particular risk of heart disease, can HRT still help?
Q 27. 6 Do progestogens taken in combination with oestrogen replacement therapy have an adverse effect on heart protection?
Q 27. 7 How long should HRT be taken to reduce the risk of heart disease?
Q 27. 8 Is there any evidence that HRT will protect my bones?
Q 27. 9 Would the dose (strength) of my HRT influence its ability to protect my bones?
Q 27. 10 Are there other treatments apart from HRT for osteoporosis?
Q 27. 11 Would HRT help my skin?
Q 27. 12 Can hormone replacement therapy cure all my menopausal symptoms?
Q 27. 13 How prevalent is cancer of the breast?
Q 27. 14 What factors influence the chance of breast cancer developing?
Q 27. 15 What is the relationship between HRT and breast cancer?
Q 27. 16 I have benign breast disease. Can I take HRT?
Q 27. 17 Does a history of breast cancer mean that HRT is absolutely contraindicated?
Q 27. 18 If I started HRT early (aged 30 to 45), does this influence my chance of developing breast cancer?
Q 27. 19 Does hormone replacement therapy increase the risks of cancer of the womb?
Q 27. 20 I have had endometrial cancer and now have menopausal problems. Can I take HRT?
Q 27. 21 Does HRT have a relationship to ovarian cancer?
Q 27. 22 How does HRT relate to a blood clot (DVT - deep venous thrombosis or pulmonary embolism)?
Q 27. 23 I have varicose veins. Can I take HRT?
Q 27.24 Should HRT be discontinued before I have a major operation or leg surgery?
Q 27. 25 Does HRT increase life-expectancy?
Q 27. 26 I am still seeing periods. Could HRT have any benefits for me?
Q 27. 27 I have been told that I have fibroids. Can I take HRT?
Q 27. 28 What happens if I decide not to take HRT?
Q 27. 29 Doctors seem to promote HRT but the media cause me anxiety. Who is right?
Q 27. 30 Support Groups.

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