Am J Cardiol. 1998 Mar 1;81(5):582-7.
Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)
Jones P, Kafonek S, Laurora I, Hunninghake D.
Baylor College of Medicine, The Methodist Hospital, Houston, Texas 77030, USA.
The objective of this multicenter, randomized, open-label, parallel-group, 8-week study was to evaluate the comparative dose efficacy of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor atorvastatin 10, 20, 40, and 80 mg compared with simvastatin 10, 20, and 40 mg, pravastatin 10, 20, and 40 mg, lovastatin 20, 40, and 80 mg, and fluvastatin 20 and 40 mg. Investigators enrolled 534 hypercholesterolemic patients (low-density lipoprotein [LDL] cholesterol > or = 160 mg/dl [4.2 mmol/L] and triglycerides < or = 400 mg/dl [4.5 mmol/L]). The efficacy end points were mean percent change in plasma LDL cholesterol (primary), total cholesterol, triglycerides, and high-density lipoprotein cholesterol concentrations from baseline to the end of treatment (week 8). Atorvastatin 10, 20, and 40 mg produced greater (p < or = 0.01) reductions in LDL cholesterol, -38%, -46%, and -51%, respectively, than the milligram equivalent doses of simvastatin, pravastatin, lovastatin, and fluvastatin. Atorvastatin 10 mg produced LDL cholesterol reductions comparable to or greater than (p < or = 0.02) simvastatin 10, 20, and 40 mg, pravastatin 10, 20, and 40 mg, lovastatin 20 and 40 mg, and fluvastatin 20 and 40 mg. Atorvastatin 10, 20, and 40 mg produced greater (p < or = 0.01) reductions in total cholesterol than the milligram equivalent doses of simvastatin, pravastatin, lovastatin, and fluvastatin. All reductase inhibitors studied had similar tolerability. There were no incidences of persistent elevations in serum transaminases or myositis.
Please click on the required question.
- 1 What will happen to me at my menopause?
- 2 Why does nature put women through the menopause?
- 3 Is life-expectancy changing?
- 4 What happens to my reproductive hormones at the menopause?
- 5 What non-hormonal changes occur at the menopause?
- 6 What problems might I have as a result of my menopause?
- 7 When am I likely to reach my menopause?
- 8 What is a premature menopause?
- 9 What are hot flushes and will HRT reduce them?
- 10 What causes hot flushes and night sweats?
- 11 Can my bladder problems be related to the menopause?
- 12 Can the menopause be associated with psychological problems.
- 13 How long can my menopausal (climacteric) symptoms last?
- 14 Is there a test that will accurately determine when my menopause has occurred?
- 15 Is it normal to experience heavy periods before the menopause?
- 16 How are heavy periods around the time of the menopause treated?
- 17 Is there a need to investigate vaginal bleeding after the menopause (postmenopausal bleeding)?
- 18 What could be the cause of vaginal bleeding after the menopause?
- 19 What is atrophic vaginitis?
- 20 What local genital symptoms can be associated with the menopause?
- 21 I have gone through the menopause and now have some bleeding (postmenopausal bleeding PMB). What will my gynaecologist wish to do?
- 22 Could I have any other long-term medical problems resulting from my menopause?
- 23 What is coronary heart disease?
- 24 What is osteoporosis?
- 25 Where else can I obtain further information?
- 26 Could I have some recommended menopause support groups.
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I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.
