Antidepressants and anxiolytic drugs have not been shown to be consistently effective in true PMS. They may have a place in secondary PMS where there are underlying psychological problems which become worse premenstrually.
Abnormality in neurotransmitters (chemicals within the brain) has been demonstrated in PMS. Psychotherapeutic agents, including fluoxetine (Prozac Dista) and paroxetine (Seroxat SmithKline Beecham), that selectively inhibit re-uptake of serotonin are under investigation in the management of PMS. Serotonin is one of these neurotransmitters.
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