Q 25. 8 Could suppressing my menstrual cycle reduce my PMS problems? |
BMJ. 1999 May 22;318(7195):1375-81.
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Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review.
Authors:
Wyatt KM,Dimmock PW,Jones PW,Shaughn O'Brien PM.
Academic Department of Obstetrics and Gynaecology, North Staffordshire Hospital, Stoke on Trent ST4 6QG.
Objectives:
To evaluate the efficacy of vitamin B-6 in the treatment of premenstrual syndrome.
Design:
Systematic review of published and unpublished randomised placebo controlled trials of the effectiveness of vitamin B-6 in the management of premenstrual syndrome.
Subjects:
Nine published trials representing 940 patients with premenstrual syndrome.
Settings, Design and Main Outcome Measures:
Proportion of women whose overall premenstrual symptoms showed an improvement over placebo. A secondary analysis was performed on the proportion of women whose premenstrual depressive symptoms showed an improvement over placebo.
Results:
Odds ratio relative to placebo for an improvement in overall premenstrual symptoms was 2.32 (95% confidence interval 1.95 to 2.54). Odds ratio relative to placebo for an improvement in depressive symptoms was 1.69 (1.39 to 2.06) from four trials representing 541 patients.
Conclusion:
Conclusions are limited by the low quality of most of the trials included. Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression.

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