Maturitas. 2006 Nov 1;55 Suppl 1:S55-63.
Vitex agnus castus: Successful treatment of moderate to severe premenstrual syndrome.
Prilepskaya VN, Research Centre for Obstetrics, Gynaecology and Perinatology, The Russian Academy of Medical Sciences, ul. Akademika Oparina 4, 117 9978 Moscow, Russia.
To assess efficacy and tolerability of a special extract of Vitex agnus castus (VAC, BNO 1095) in the treatment of women suffering from premenstrual syndrome (PMS) with moderate to severe complaints.
Prospective, open, non-comparative, monocentre study. After a run-in phase lasting three cycles, eligible patients were treated for up to three cycles with VAC extract. Efficacy was assessed using a PMS-Diary (primarily) and the PMTS score. One hundred and twenty-one patients were enrolled, 118 provided efficacy data (full analysis set), and 109 completed the treatment phase. The severity of the PMS symptoms consistently decreased during treatment, on average from 22.8 score points during the baseline cycle to 10.2 during the third cycle. The mean decrease was 12.6 score points (95% CI: 10.9-14.4, p<0.0001, Student's t-test). Response to treatment was found in 67.8% of the women during the third treatment cycle (95% CI: 58.6-77.0). Results for the PMTS were similar with a decrease on average from 22.5 to 11.0 score points, i.e. mean change -11.4 (95% CI: 10.1-12.8, p<0.0001). Vitex agnus castus extract BNO 1095 is effective and well tolerated in the treatment of moderate to severe PMS.
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- Premenstrual Syndrome - PMS What is The Premenstrual Syndrome (PMS)
- 2 How prevalent is PMS?
- 3 How can we tell if I have PMS?
- 4 How can my PMS be evaluated?
- 5 How can cyclical breast pain (mastalgia) be treated?
- 6 How can my PMS be treated?
- 7 What is the place of progestogens and progesterone in the management of PMS?
- 8 Could suppressing my menstrual cycle reduce my PMS problems?
- 9 Could a diuretic help my PMS?
- 10 Is there a place for anti-depressants or anxiolytic drugs in the management of PMS?
- 11 Is there a place for removing my ovaries in the management of PMS?
- 12 What can be done about my decreased libido (sex drive)
- 12A What is the place of Viagra (sildenafil citrate) in sexual dysfunction in women?
- 13 How is PMS treatment monitored?
- 14 How long should PMS treatment be taken?
- 15 What is the chronic fatigue syndrome?
- 16 What is seasonal affective disorder (SAD)
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This is the personal website of David A Viniker MD FRCOG, retired Consultant Obstetrician and Gynaecologist - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.
- Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.
The aim of this web site is to provide a general guide and it is not intended as a substitute for a consultation with an appropriate specialist in respect of individual care and treatment.
David Viniker retired from active clinical practice in 2012.In 1999, he setup this website - www.2womenshealth.com - to provide detailed
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