Authors:
Donnez J. Vilos G. Gannon MJ. Stampe-Sorensen S. Klinte I. Miller RM.
Institution:
Dr. J. Donnez, Service de Gynecologie, University St. Luc, Brussels; Belgium.
Title:
Goserelin acetate (Zoladex) plus endometrial ablation for dysfunctional uterine bleeding: A large randomized, double-blind study (1997-1788).
Source:
Fertility and Sterility. Vol 68(1) (pp9-36), 1997.
Abstract:
Objectives:
To confirm the advantages of goserelin prior to endometrial ablation for the treatment of dysfunctional uterine bleeding.
Design:
Multicenter, prospective, randomized, double-blind study.
Patients:
Cycling premenopausal women with dysfunctional uterine bleeding. Treatment: Patients were randomized to goserelin or placebo (sham depot) once monthly for 2 months prior to endometrial ablation. Treatment was timed to allow surgery 6 weeks later on day 7 of the menstrual cycle.
Main Outcome Measure(s):
Amenorrhea rates, endometrial histology and thickness, pain and blood loss scores, and surgical parameters.
Results:
At 24 weeks after surgery, significantly more goserelin than placebo patients experienced amenorrhea (40% versus 26%). Blood loss was reduced from baseline, but not different between the groups. At surgery, mean endometrial thickness was 1.6 mm and 3.4 mm for the goserelin and placebo groups, respectively, with significantly more atrophic glands and stroma in the goserelin group. Surgery was significantly shorter (by 22%) and easier in the goserelin than in the placebo group, with a significantly lower median fluid absorption in the goserelin groups. In both groups, pain scores were reduced, patient satisfaction was high (> 92%), and re-intervention rate was low (2.8%).
Conclusion(s):
Goserelin in combination with endometrial ablation was superior to endometrial ablation alone for the treatment of dysfunctional uterine bleeding.
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- 17 How do the various medical treatments for heavy periods work?
- 18 What would be reasonable initial treatment for a teenager or young woman with heavy periods?
- 19 What is a hysterectomy?
- 20 What are the indications for hysterectomy?
- 21 What are the risks (complications) of hysterectomy?
- 22 What is vault granulation?
- 23 What are the different types of hysterectomy?
- 24 Is it essential to remove the neck of the womb at hysterectomy?
- 25 Should my ovaries be removed or conserved during hysterectomy?
- 26 How long will I be in hospital when I have my hysterectomy?
- 27 I have had a hysterectomy. Do I still need to have smear tests?
- 28 What are the other surgical alternatives to hysterectomy?
- 29 How do endometrial ablation and hysterectomy compare?
- 30 Are there any psychological effects following hysterectomy?
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- 32 Could I have some recommended hysterectomy support groups?
- 33 Are there any support groups?
- Intermenstrual Bleeding - Bleeding between periods.
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