What treatments are available for pre-malignant conditions of the cervix?

Br J Obstet Gynaecol. 1998 Sep;105(9):1022-5.

Do routine antibiotics after loop diathermy excision reduce morbidity?

Foden-Shroff J , Redman CW , Tucker H , Millinship J , Thomas E , Warwick A , Jones PW .

Department of Obstetrics and Gynaecology, North Staffordshire Hospital NHS Trust, Harpfields, Stoke on Trent, UK.

Objectives:

To evaluate whether routinely giving an antibiotic after loop diathermy excision of the cervical transformation zone reduced post-operative vaginal loss.

Design:

Prospective, randomised, double-blind placebo controlled parallel study.

Participants:

Five hundred women undergoing loop diathermy excision in a colposcopy clinic.

Intervention:

Administration of either ofloxacin 400 mg (2x200 mg) once daily for 5 days or an identical placebo.

Main Outcome Measure:

Vaginal loss, assessed using a pictorial chart.

Results:

No significant difference in post-operative vaginal loss was found.

Conclusion:

Routine antibiotic prophylaxis after loop diathermy excision is not justified.

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