Authors

Ashok PW. Templeton A.

Institution:

Dr. P.W. Ashok, Department of Obstetrics Gynaecology, University of Aberdeen,

Aberdeen Maternity Hospital, Cornhill Road, Aberdeen AB25 2ZD; United

Kingdom.

Title:

Nonsurgical mid-trimester termination of pregnancy: A review of 500 consecutive cases. (1999 2713)

Source:

British Journal of Obstetrics and Gynaecology. Vol 106(7) (pp06-710), 1999.

Abstract:

Objective. To assess the effectiveness of a regimen comprising mifepristone followed by a combination of the vaginal and oral administration of misoprostol for mid-trimester medical termination of pregnancy. Design. Retrospective analysis of prospectively collected data in women undergoing mid-trimester medical termination of pregnancy. Setting. Aberdeen Royal Infirmary, Scotland. Sample. A consecutive series of 500 women with pregnancies of 13-21 weeks of amenorrhea undergoing legally induced abortion in one Scottish NHS hospital. Methods. Each woman received a single oral dose of mifepristone 200 mg and 36-48 h later vaginal misoprostol 800 mug. Three hours following the first dose of misoprostol, 400 mug doses were administered orally at three hourly intervals, to a maximum of four doses. Success was defined as abortion occurring with five doses of prostaglandin, or within 15 h of administration of the first dose of prostaglandin.

Results:

Ninety-seven percent aborted successfully. The median dose of misoprostol required was 1200 mug and the median induction-to-abortion interval after first prostaglandin administration was 6.5 h. The median number of doses of misoprostol required to induce abortion, and the induction-to-abortion interval, was statistically significantly higher among women at gestations 17-21 weeks than among those at 13-16 weeks (P = 0.0001). A total of 9.4% required surgical evacuation of the uterus under general anaesthesia and 66.4% of the women were managed as day cases. Conclusions. The combination of oral mifepristone 200 mg followed by vaginally and orally administered misoprostol provides a noninvasive and effective regimen for second trimester termination of pregnancy.


women's health



Please click on the required question.

Women's Health

Thank you for choosing to visit us.


This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.

I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.

Women's Health





Your Own Web Presence

 

For £35

 

 

FirstWebSiteDesign.com

 

Have your own web ad on the internet and optimized for good positioning.

 

Your Own Dedicated Web Page Designed Specifically For You

 

More Effective

Than Your Own

Single Page Website

 

For £35

 

 

FirstWebSiteDesign.com