Authors:
Corson SL.
Institution
Philadelphia Fertility Institute, 815 Locust St.,Philadelphia, PA 19107; United States.
Title:
Efficacy and safety of a monophasic and a triphasic oral contraceptive containing norgestimate (1994-2109c).
Source:
American Journal of Obstetrics and Gynecology. Vol 170(5 II) (pp556-1561), 1994.
Abstract:
Both monophasic and triphasic formulations of ethinyl estradiol plus norgestimate, a progestin with marked progesterone-receptor affinity and minimal androgen-receptor affinity, have been evaluated in numerous clinical studies designed to determine if norgestimate's receptor-binding profile provides enhanced safety without a reduction in efficacy. To date clinical trials have shown that both formulations of ethinyl estradiol/norgestimate offer contraceptive efficacy e quivalent to that of other oral contraceptives. Monophasic ethinyl estradiol/norgestimate was associated with an incidence of breakthrough bleeding and spotting similar to that of monophasic ethinyl estradiol/norgestrel and an incidence of amenorrhea less than that of ethinyl estradiol/norgestrel. Cycle control with triphasic ethinyl estradiol/norgestimate was similar to that with monophasic ethinyl estradiol/norgestimate. Weight gain and elevated blood pressure were insignificant in clinical trials with both fixed-dose and phasic ethinyl estradiol/norgestimate formulations. Perhaps of greatest importance, both monophasic and triphasic ethinyl estradiol/norgestimate formulations consistently showed favorable impact on metabolic parameters, including elevations in serum high-density lipoprotein cholesterol, and reductions in the low-density lipoprotein/high-density lipoprotein ratio, the parameter considered most sensitive for atherosclerotic risk. Both monophasic and triphasic ethinyl estradiol/norgestimate formulations were associated with minimal and clinically neutral effects on carbohydrate metabolism.
Please click on the required question.
- 1 What is an oral contraceptive?
- 2 How popular are oral contraceptive pills?
- 3 What are the benefits of the combined oral contraceptive pill?
- 4 Will the combined oral contraceptive pill improve my periods?
- 5 Could the combined oral contraceptive pill change my libido (sex drive)
- 6 What are the risks of taking combined oral contraceptive pills?
- 7 What side effects could I have whilst taking the combined oral contraceptive pill?
- 8 What is the effect of the combined oral contraceptive pill on body weight?
- 9 Will the combined oral contraceptive pill increase my vaginal discharge?
- 10 Does the combined oral contraceptive pill increase the chance of pelvic infections?
- 11 What is the relationship between the combined oral contraceptive pill and fibroids?
- 12 Could a combined oral contraceptive pill increase my blood pressure?
- 13 Do combined oral contraceptive pills have any effect on the blood?
- 14 What is the relationship between the combined oral contraceptive pill and thromboembolism?
- 15 What is the relationship between the combined oral contraceptive pill and heart attacks?
- 16 What is the relationship between the combined oral contraceptive pill and strokes?
- 17 Does the combined oral contraceptive pill affect the breasts?
- 18 Could I feel depressed as a result of taking the combined oral contraceptive pill?
- 19 What is the relationship between the combined oral contraceptive pill and cancer of the ovary?
- 20 What is the relationship between the combined oral contraceptive pill and cancer of the uterus?
- 21 What is the relationship between the combined oral contraceptive pill and cancer of the cervix?
- 22 What is the relationship between the combined oral contraceptive pill and cancer of the breast?
- 23 Family Planning Support Groups.
- 24 Support Groups.
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