Can an autoimmune problem cause recurrent miscarriages?

• Introduction
• Abortion
• Amenorrhoea
• Birth Control
• Bladder Symptoms
• Cancer in Women
• Childbirth
• Children and Teenagers
• Diet / Weight Loss
• Dysmenorrhoea
• Endometriosis
• Fibroids
• HRT
• Hirsutism
• Hysterectomy
• Infections
• Infertility
• Medication Drugs
• Menopause
• Menorrhagia
• Miscarriage
• Definition
• Prevalence
• Cause
• Symptoms
• Types of Miscarriage
• Spontaneous Miscarriage
• Threatened Miscarriage
• Treatment of Miscarriage
• Recurrent Miscarriage
• Miscarriage and Depression
• Ectopic Pregnancy
• Blighted Ovum
• Hydatidiform Mole
• Pregnancy Tests
• Pregnancy after Miscarriage
• Support Groups
• Painful Sex
• Pap Smear Test
• PCOS
• Pelvic Pain
• PMS
• Postpartum
• Pregnancy
• Self Esteem
• Sexual Problems
• Vaginal Discharge
• Vaginal Prolapse
• Vulval Symptoms

Authors:

Ogasawara MS. Aoki K. Katano K. Ozaki Y. Suzumori K.

Institution

Dr. M.S. Ogasawara, Dept. Obstetrics and Gynecology II, Nagoya City Johsai Hospital, University Medical School, Mizuho-ku, Nagoya 4678601; Japan.

Title:

Factor XII but not protein C, protein S, antithrombin III, or factor XIII is a predictor of recurrent miscarriage (2001-3360).

Source:

Fertility and Sterility. Vol 75(5) (pp16-919), 2001.

Abstract:

Objectives:

To investigate whether a decrease in the values of protein C (PC), protein S (PS), antithrombin III (ATIII), factor XII (FXII), or factor XIII (FXIII) has predictive value for subsequent miscarriages.

Design:

Prospective study.

Setting:

Nagoya City University Medical School.

Patients:

A total of 536 patients with a history of two or more first-trimester miscarriages: Intervention(s): One hundred and twelve patients treated with low-dose aspirin were excluded from the analysis.

Main Outcome Measure(s):

The subsequent pregnancy outcome of 424 patients was compared for abnormal and normal levels of each parameter.

Results:

There were no differences in the subsequent miscarriage rates between abnormal and normal values of PC, PS, ATIII, and FXIII. However, the rate with abnormal FXII is significantly higher than that with normal FXII.

Conclusion(s):

A decrease in FXII (but not in PC, PS, ATIII, or FXIII) predicts subsequent miscarriage in patients with a history of first-trimester recurrent miscarriages. Copyright (C) 2001 American Society for Reproductive Medicine.