Fertil Steril. 2009 Jul 29. [Epub ahead of print]
Please click on the required question. Thank
you for choosing to visit us. This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT. I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.
Etiology of recurrent pregnancy loss in women over the age of 35 years.
Marquard K, Westphal LM, Milki AA, Lathi RB.
Washington University School of Medicine, St. Louis, Missouri.
OBJECTIVE: To determine the rate of embryonic chromosomal abnormalities,
thrombophilias, and uterine anomalies in women over the age of 35 years with
recurrent pregnancy loss (RPL). DESIGN: Retrospective cohort study. SETTING:
Academic reproductive endocrinology and infertility clinic. PATIENT(S): Women
>/=35 years old with >/=3 first trimester miscarriages. INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Age, number of prior losses, cytogenetic testing of the
products of conception (POC), uterine cavity evaluation, parental karyotype, TSH,
and antiphospholipd antibody (APA) and thrombophilia testing. Aneuploidy in the
POC in women with RPL was compared with sporadic miscarriages (</=2 losses) in
women >/=35 years. RESULT(S): Among 43 RPL patients, there were 50 miscarriages
in which cytogenetic analysis was performed. In the RPL group, the incidence of
chromosomal abnormalities in the POC was 78% (39 out of 50) compared with a 70%
incidence (98 out of 140) in the sporadic losses. Thrombophilia results in the
RPL patients were normal in 38 patients, four patients had APA syndrome, and one
had protein C deficiency. Forty out of 43 had normal uterine cavities. Both TSH
and parental karyotypes were normal in all of the patients tested. When the
evaluation of RPL included karyotype of the POC, only 18% remained without
explanation. However, without fetal cytogenetics, 80% of miscarriages would have
been unexplained. CONCLUSION(S): In older patients with RPL, fetal chromosomal
abnormalities are responsible for the majority of miscarriages. Other causes
were present in only 20% of cases.
- Introduction
- Abortion
- Amenorrhoea
- Birth Control
- Bladder Symptoms
- Cancer in Women
- Childbirth
- Children and Teenagers
- Diet / Weight Loss
- Dysmenorrhoea
- Endometriosis
- Fibroids
- HRT
- Hirsutism
- Hysterectomy
- Infections
- Infertility
- Medication Drugs
- Menopause
- Menorrhagia
- Miscarriage
- Definition
- Prevalence Prevalence
- Cause
- Symptoms
- Types of Miscarriage
- Spontaneous Miscarriage
- Threatened Miscarriage
- Treatment of Miscarriage
- Recurrent Miscarriage
- Miscarriage and Depression
- Ectopic Pregnancy
- Blighted Ovum
- Hydatidiform Mole
- Pregnancy Tests
- Pregnancy after Miscarriage
- Support Groups
- Painful Sex
- Pap Smear Test
- PCOS
- Pelvic Pain
- PMS
- Postpartum
- Pregnancy
- Self Esteem
- Sexual Problems
- Vaginal Discharge
- Vaginal Prolapse
- Vulval Symptoms
Underperforming Family Website?
Visit
KeywordSEOPro.com - SEO Keyword Tool & SEO Tips
Now
Promote Your
Family Website
Improve Your Business Income
