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Ann Genet. 1993;36(2):107-10 Cytogenetic findings in
echographically defined blighted ovum abortions.Minelli E, Buchi
C,Granata P,Meroni E,Righi R,
Portentoso P,Giudici A,Ercoli A,Sartor
MG,Rossi A, et al.
Laboratorio Analisi, Sezione di Genetica, Ospedale di Circolo, Varese Italy.
A sample of 52 spontaneous blighted ovum abortions (BO) was examined
cytogenetically and compared with a sample of abortions with echographic
evidence of the embryo (AE). Abnormal karyotypes were 67% in the BO sample and
53% in the AE sample, a non significant difference. In the BO abortions
trisomies were 74% of the abnormal karyotypes but 35% in the AE abortion, and
the 45,X karyotype was absent among the BO but was found in 10 cases of AE. The
prevalence of trisomies 16 and 22 in the BO abortions indicates that genes on
these chromosome may be responsible for the early arrest of embryonic
development.

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