What are in vitro fertilisation (IVF) and embryo transfer?

Fertil Steril. 1999 Aug;72(2):218-20.

Is blastocyst transfer useful as an alternative treatment for patients with multiple in vitro fertilization failures?Cruz JR,Dubey AK, Patel J, Peak D,Hartog B,Gindoff PR.

Department of Obstetrics and Gynecology, George Washington University Medical Center, Washington, D.C. 20037, USA.

Objectives:

To determine whether blastocyst transfer is of benefit to patients with multiple IVF failures.

Design:

Retrospective cohort study.

Setting:

The George Washington University Medical Center.

Patients:

Patients undergoing IVF between October 1, 1997, and November 30, 1998, who had previously undergone three or more unsuccessful IVF cycles. Patients who had at least three embryos at the 8- to 12-cell stage available on day 3 were eligible for the study.

Intervention(s):

Patients were given the option of day 3 ET (group A) or blastocyst transfer (group B).

Settings, Design and Main Outcome Measures:

Blastocyst-formation rate, clinical pregnancy rate (PR) per transfer, and implantation rate per transfer.

Result(s):

Groups A and B were similar in terms of age, the number of previous failed IVF cycles, fertilization rate, and the number of fertilized oocytes per cycle. The blastocyst-formation rate was 51.0%. Clinical pregnancy and implantation rates per transfer were statistically significantly higher in the blastocyst-transfer group. There were no multiple pregnancies after blastocyst transfer.

Conclusion:

Blastocyst transfer increases implantation rates and PRs in patients with multiple failed IVF cycles, without increasing the risk of multiple pregnancy.

See Also:

• Infertility Causes - Treatment
• Infertility - Anovulation - Egg release Problems
• Infertlity - Tubal Problems
• Infertility - Male Factor
  
  
  

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