Authors:
Asch RH. Li H-P. Balmaceda JP. Weckstein LN. Stone SC.
Institution:
"center" for Reproductive Health, UCI Medical "center", Pavilion 11, 101 The City Drive, Orange, CA 92668; United States.
Title:
Severe ovarian hyperstimulation syndrome in assisted reproductive technology: Definition of high risk groups (1991-235).
Source:
Human Reproduction. Vol 6(10) (pp395-1399), 1991.
Abstract:
In a retrospective analysis of 637 cycles of ovarian stimulation and transvaginal follicular aspiration for various assisted reproductive technologies, severe ovarian hyperstimulation syndrome (SOH) occurred in six (0.94%) cycles. The patients at a high risk of developing SOH in cycles of assisted reproduction were those who had excessive serum oestradiol levels on the day of human chorionic gonadotrophin (HCG) administration (oestradiol > 6000 pg/ml; 38% SOH) and a high number of oocytes obtained (>30 oocytes; 23% SOH). In those patients with both oestradiol > 6000 pg/ml on the day of HCG administration and >30 eggs retrieved, the chance of developing SOH was 80%. The higher the serum oestradiol levels and the more eggs retrieved, the higher the pregnancy rates observed. High oestradiol level did not appear to have a detrimental effect on pregnancy rates and outcome. Furthermore, our results are not consistent with suggestions that the addition of gonadotrophin-releasing hormone agonist to ovarian stimulation protocols, follicular aspiration and/or luteal support with progesterone may reduce the incidence of ovarian hyperstimulation syndrome.
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