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The risks of gonadotrophin therapy are:

  • multiple pregnancy (twins, triplets etc.): rates are higher with gonadotrophins than clomiphene.
  • ovarian hyperstimulation syndrome (OHSS) is more commonly associated with polycystic ovary syndrome and accordingly for these women, the quantity of gonadotrophin administered should be reduced. Some units continue to monitor oestrogen levels in addition to ultrasound but it has been shown that ultrasound alone can be used safely and efficiently.

As with clomiphene (8), there is concern that gonadotrophin therapy may be associated with an increased risk of ovarian cancer although the latest data does not support the earlier anxieties.

Related Medical Abstracts - Click on the paper title:-


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