How does metformin work for PCOS?

Metformin has recently become recognised as potentially beneficial for women with infertility and PCOS (Q7.14). This syndrome appears to be related to insulin resistance, which is reversed by the metformin. Early reports are encouraging. As metformin works by reversing the underlying disease process rather than specifically inducing ovulation, it seems likely that it will not be associated with the risks of ovulation induction (8).

The role of metformin in polycystic ovary syndrome: a systematic review.(2007-02)
Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome. (2007-01)
Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome? (2006-01)
Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome. (2006-02)
Effects of metformin on insulin resistance, androgen concentration, ovulation and pregnancy rates in women with polycystic ovary syndrome following laparoscopic ovarian drilling. (2006-03)
Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review. (2006-04)
Metformin in the treatment of clomiphene citrate-resistant women with high BMI and primary infertility: clinical results and reproductive outcome. (2005-01)
Metformin administration and laparoscopic ovarian drilling improve ovarian response to clomiphene citrate (CC) in oligo-anovulatory CC-resistant women with polycystic ovary syndrome. (2005-02)
Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. (2005-03)
Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome? (2004-01)
Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome: a prospective parallel randomized double-blind placebo-controlled trial. (2004-02)
Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome.(2004-03)
Medical vs. surgical treatment for clomiphene citrate-resistant women with polycystic ovary syndrome. (2003-01)
Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome. (2002-01)
Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. (2001-01)
Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome. (1999-02)

See Also:

Infertility Causes - Treatment

Infertility - Anovulation - Egg release Problems

Infertlity - Tubal Problems

Infertility - Male Factor

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