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Int J Gynaecol Obstet. 2008 Sep;102(3):284-6.
Comparison of oral naproxen and intrauterine lignocaine instillation for pain
relief during hysterosalpingography.
Gupta N, Ghosh B, Mittal S.
Department of Obstetrics and Gynecology, All India Institute of Medical
Sciences, New Delhi, India.
Objectives: To compare the efficacy of oral naproxen with intrauterine
instillation of 1% lignocaine for pain relief in women undergoing
hysterosalpingography (HSG) as an infertility investigation. Methods: One
hundred women undergoing HSG were randomly allocated into 2 groups. Group A (n =
50) underwent intrauterine instillation of 5 mL of 1% lignocaine 2 minutes prior
to the procedure, while the women in group B (n = 50) were instructed to
self-administer a single oral dose of 375 mg of naproxen 1 hour prior to HSG.
Pain scores immediately after the procedure (0 minutes) and delayed pain scores
(30 minutes) were recorded and compared. Results: Women in both groups were
comparable in age and parity. The mean +/- SD pain scores in group A and group B
at 0 minutes and 30 minutes were not significantly different (P = 0.12 and P =
0.07). Conclusion: Intrauterine lignocaine was no more effective than oral
naproxen for pain relief during HSG.

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