Authors:

Erenus M. Yucelten D. Gurbuz O. Durmusoglu F. Pekin S.

Institution

Hamam sokak, Caddebostan, Istanbul; Turkey.

Title:

Comparison of spironolactone-oral contraceptive versus cyproterone acetate-estrogen regimens in the treatment of hirsutism (1996-1526).

Source:

Fertility and Sterility. Vol 66(2) (pp16-219), 1996.

Abstract:

Objectives:

To compare the efficacy of two antiandrogens, cyproterone acetate (CPA) and spironolactone, in the treatment of hirsutism.

Design:

Prospective randomized single-blinded study.

Setting:

A tertiary hirsutism clinic.

Patients:

Forty-two premenopausal patients with hirsutism were selected.

Interventions:

Subjects were randomized to receive either 100 mg spironolactone and an oral contraceptive (OC) containing 150 mug desogestrel and 30 mug ethinyl E2 or 50 mg CPA daily on days 1 to 10 of the menstrual cycle, which was administered with 35 mug ethinyl E2 daily on days 1 to 21.

Settings, Design and Main Outcome Measures:

Hirsutism scores were measured according to Ferriman- Gallwey scoring system and side effects were monitored for 9 months of treatment. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters.

Results:

Hirsutism scores were decreased significantly in both groups at the end of 9 months. The percent of change in hirsutism scores in CPA and spironolactone group were as follows: 19.23% +/- 14.77% and 24.48% +/- 14.27% at 3 months; 39.01% +/- 19.77% and 37.46% +/- 16.90% at 6 months; and 51.89% +/- 20.87% and 46.39% +/- 16.10% at 9 months, respectively. There was a trend toward a better response with CPA treatment, which did not achieve significance. None of the patients stopped treatment because of side effects.

Conclusion:

The present data suggest that both spironolactone and CPA were similarly effective in treatment of hirsutism.




See Also:

Hirsutism

Alopecia

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