Fertil Steril. 2005 Dec;84(6):1693-7.

Comparison of the clinical efficacy of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism: a randomized controlled study.

Inal MM,Yildirim Y,Taner CE.

Social Security Agency, Department of Reproductive Endocrinology and Infertility, Aegean Obstetrics and Gynecology Teaching Hospital, Izmir, Turkey.

Objectives:

To compare the effectiveness of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism (IH).

Design:

Prospective randomized clinical study.

Setting:

Social Security Agency, Aegean Obstetrics and Gynecology Teaching Hospital, Department of Reproductive Endocrinology and Infertility, a tertiary referral center.

Patients:

Eighty women with IH who had been admitted to our center.

Intervention(s):

Patients were randomly and e Qually assigned to receive flutamide (250 mg/d for the first 10 days of the cycle) and spironolactone plus Diane 35 (spironolactone 100 mg/d; Diane 35 is a combination tablet of 2 mg cyproterone acetate and 35 microg ethinylestradiol/d) for 9 months.

Settings, Design and Main Outcome Measures:

Modified Ferriman-Gallwey (F-G) score and hormonal profile before treatment and at the end of treatment.

Result(s):

In spite of the fact that there were no statistically significant differences in modified F-G scores in between the two groups, a significant decrease in modified F-G scores was observed in the flutamide (from 19.93 +/- 4.31 to 15.58 +/- 4.28) and spironolactone plus Diane 35 (from 18.77 +/- 3.76 to 14.54 +/- 3.29) groups. There were also no differences between the two groups with respect to hormonal profiles including serum FSH, LH, free T, 17-OH-progesterone, and DHEAS levels. No major side effect, including liver toxicity, was observed in either group.

Conclusion(s):

Our data suggest that both therapies have similar effectiveness in the treatment of IH.





See Also:

Hirsutism

Alopecia

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