Authors:
Velazquez EM. Acosta A. Mendoza SG.
Institution:
Dr. E. M.
Velazquez, Centro Endocrinologia/Reproduccion, Av 4, 34-2, Merida
5101-A; Venezuela.
Title:
Menstrual cyclicity after metformin therapy in polycystic ovary syndrome.
Source:
Obstetrics and Gynecology. Vol 90(3) (pp92-395), 1997.
Abstract:
Objectives:
To assess the effect of insulin-lowering treatment on menstrual cyclicity in polycystic ovary syndrome (PCOS).
Methods:
Forty oligoamenorrheic women with PCOS were recruited in a prospective clinical study to receive met formin for a minimum period of 6 months. Twenty-two women completed the study. Serum LH, FSH, free testosterone, and glucose and insulin response to oral glucose load were measured both before and after 8 weeks of metformin treatment. Menstrual cyclicity and serum progesterone levels at the midluteal phase were assessed at the 30th week of metformin treatment.
Results:
Twenty-one of 22 women had restoration of menstrual cyclicity (95.7%). Four of these women (19%) became pregnant within the 6th and 7th months of treatment. All four of the pregnant women delivered, and the infants were healthy. Thirteen of 15 women who had regular menses demonstrated a serum progesterone level within the ovulatory range (3.1-28 ng/mL). Fasting (P<.001) and the integrated insulin response to the glucose load decreased (P<.001) after 8 weeks of metformin treatment. This was accompanied by significant decreases in serum LH (P<.001) and free testosterone (P<.001) levels and LH/FSH ratio (p<.001). There was a small but significant reduction in body mass index after 8 weeks of metformin treatment (P<.001).
Conclusion:
A 6-month course of metformin may improve menstrual cyclicity and fertility in women with the PCOS. Insulin-sensitizing agents provide a rational approach to the treatment of the metabolic and endocrine abnormalities in PCOS women.
See Also:
PCOS - Polycystic Ovary Syndrome
Thank you for choosing to visit us.
This is the personal website of David A Viniker MD FRCOG, retired Consultant Obstetrician and Gynaecologist - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.
- Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.
I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.
The aim of this web site is to provide a general guide and it is not intended as a substitute for a consultation with an appropriate specialist in respect of individual care and treatment.
David Viniker retired from active clinical practice in 2012.
In 1999, he setup this website - www.2womenshealth.com - to provide detailed
information many of his patients requested. The website attracts thousands of visitors every day from around the world.
If you would like advice on how to make more from your website, please visit his website Keyword SEO PRO or email him on david@page1-on-google.com.
 |