PCOS - Polycystic Ovary Syndrome

PCOS - Polycystic Ovary Syndrome



How does metformin help for PCOS?

Please subscribe to receive our FREE women's health newsletter.
STAY UP TO DATE on the important issues affecting YOUR HEALTH.
First Name:
Family Name:
Email:
Profession:
Country:
Age:
Home
Women's Health Update Blog
Abortion
Amenorrhoea - Absent Periods
Birth Control
Bladder Symptoms
Cancer in Women
Diet / Weight Loss
Dysmenorrhoea
Ectopic Pregnancy
Female Sexual Problems
GUESTBOOK
HRT Risks & Benefits
Hysterectomy
Infections
Infertility
Medication - Drugs
Menopause
Menorrhagia Heavy Periods
Miscarriage
Painful Sex - Dyspareunia
Pap Smear Test
PCOS
Pelvic Pain
PMS- Premenstrual Syndrome
Pregnancy & Childbirth
Vaginal Discharge
Vaginal Prolapse
Viagra, Libido and Sex Drive.
The Author
Consultations
Contact Us

Am J Obstet Gynecol. 2006 May;194(5):1266-72.

Lipids in polycystic ovary syndrome: role of hyperinsulinemia and effects of metformin.Banaszewska B,Duleba AJ,Spaczynski RZ,Pawelczyk L.

Division of Infertility and Reproductive Endocrinology, Department of Gynecology and Obstetrics, Poznan University of Medical Sciences, Poznan, Poland.

Objectives:

Patients with polycystic ovary syndrome frequently suffer from hyperinsulinemia and adverse lipid profile. This study evaluated effects of metformin on lipid profile.

Study Design:

Lipid profiles in hyperinsulinemic (n = 43) and normoinsulinemic (n = 45) subjects were compared. Hyperinsulinemic subjects were treated with metformin (500 mg po tid) and lipid profiles were reevaluated at 3 and 6 months of treatment.

Results:

The hyperinsulinemic group had significantly lower high-density lipoprotein (HDL) (by 11%), higher total cholesterol to HDL ratio (by 23%), and greater triglycerides (by 57%) than the normoinsulinemic group. Six-month metformin therapy in hyperinsulinemic women was associated with a significant decrease of insulin level (by 35%), total cholesterol (by 11%), low-density lipoprotein (LDL) (by 12%), and triglycerides (by 33%). Levels of lipids in hyperinsulinemic women after metformin therapy were comparable to levels observed in normoinsulinemic subjects.

Conclusion:

The present study supports the notion that metformin may be considered as a prophylactic therapy lowering cardiovascular risk factors in hyperinsulinemic women with polycystic ovary syndrome.


Back Home Up Next


See Also:

PCOS - Polycystic Ovary Syndrome

Do you have an unanswered women's health question?

Please let us have your general question on our NEW FORUM / MESSAGE BOARDS facility and we will try to answer it for you. I am sure that you will appreciate that we cannot offer advice on the management of an individual's specific problem.

 

 

Please subscribe to receive our FREE women's health newsletter.
STAY UP TO DATE on the important issues affecting YOUR HEALTH.
First Name:
Family Name:
Email:
Profession:
Country:
Age:
 

DISCLAIMER

The aim of this web site is to provide a general guide and it is not intended as a substitute for a consultation with an appropriate specialist in respect of individual care and treatment.

Thank you for your visiting us at 2womenshealth.com.

This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London.

I do hope that you find the answers to your questions in the patient information and medical advice provided. If you still have unanswered questions, please consider entering them into one of our forums and I will try to assist you.

PCOS - Polycystic Ovary Syndrome