Absent and Infrequent Periods: What is oligomenorrhoea?

Papadimitriou DT,Linglart A,Morel Y,Chaussain JL.

Department of Pediatric Endocrinology, Groupe hospitalier Cochin-Saint-Vincent de Paul and Universite Paris-V, Paris, France.

Background:

Androgen receptor defects affect the regulation of the gonadotropic axis. However, little is known about the timing of pubertal maturation in complete androgen insensitivity syndrome (CAIS).

Aims:

To evaluate growth, skeletal maturation and gonadotropin and sex steroid secretion in patients with CAIS and intact gonads at puberty.

Methods:

Clinical, auxological and hormonal evaluation of 9 patients with CAIS from birth up to 17 years of age, prior to gonadectomy, in a single institution, retrospective study.

Results:

Breast development occurred at a median age of 11.1 years, thumb sesamoid appeared at 11.5 years, and peak height velocity at 12.3 years, all consistent with average female values. However, median adult male height (+1.2 SDS) was closer to the patients' male target height (-0.3 SDS). Plasma testosterone levels rose early compared to normal boys. LH (basal and GnRH-stimulated) increased rapidly, above normal male values, in early puberty.

Conclusions:

This retrospective evaluation of a limited number of cases with a heterogeneous pattern of follow-up suggests that patients with CAIS may enter puberty at an age closer to female standards. These results imply a major role of direct androgen action, in utero or in early life, in determining the pattern of pubertal gonadotropin maturation.

Related Medical Abstracts - Click on the paper title:-

• Androgen resistance. (2006-01)
• Puberty in subjects with complete androgen insensitivity syndrome. (2006-02)
• Complete androgen insensitivity syndrome: the role of the endocrine surgeon. (2005-01)
• Clinical, hormonal, behavioral, and genetic characteristics of androgen insensitivity syndrome in a Brazilian cohort: five novel mutations in the androgen receptor gene. (2003-01)
• Molecular basis of androgen insensitivity. (2001-01)

Please click on the required question.

• 1 What is amenorrhoea?
• 2  What is oligomenorrhoea?
• 3  What are true and false amenorrhoea?
• 4  What is the difference between primary and secondary amenorrhoea?
• 5  Our daughter has not started her periods yet. When should we seek medical advice?
• 6  My periods have stopped. When should I seek medical advise?
• 7  My periods have stopped. How can the cause be determined?
• 8  Can generalised ill health result cause periods to stop?
• 9  I am a keen sportswoman. Could this stop my periods?
• 10 What is hyperprolactinaemia?
• 11 Which investigations are particularly helpful in finding the cause for the cessation of my periods?
• 12 What is karyotyping?
• 13 What is Turner Syndrome?
• 14 What is the testicular feminisation syndrome?
• 15 What is the resistant ovary syndrome?
• 16 What are autoantibodies?
• 17 What is premature ovarian failure (premature menopause)
• 18 What uterine abnormalities may cause amenorrhoea?
• 19 What is Asherman's syndrome?
• 20  What are the late effects of prolonged amenorrhoea?
• 21  How can my amenorrhoea be treated?
• 22  What are the risks and benefits of hormone replacement when used for premature menopause?
• 23 My periods are coming infrequently (oligomenorrhoea). What is likely to be the causes?
• 24  How are infrequent periods investigated?
• 25  How can oligomenorrhoea be treated?
• 26  If my periods are absent or infrequent, do I need contraception?
• 27  Where can I obtain more information?
• 28  Support Groups.
  • Anorexia Nervosa
  
  
  
  
  

  Thank you for choosing to visit us.

  
  

  This is the personal website of David A Viniker MD FRCOG, Consultant Obstetrician and Gynaecologist at Whipps Cross University Hospital, London - Specialist Interests - Reproductive Medicine including Infertility, PCOS, PMS, Menopause and HRT.

  I do hope that you find the answers to your women's health questions in the patient information and medical advice provided.

Your Own Web Presence

For £35

FirstWebSiteDesign.com

Have your own web ad on the internet and optimized for good positioning.

Your Own Dedicated Web Page Designed Specifically For You

More Effective

Than Your Own

Single Page Website

For £35

FirstWebSiteDesign.com