Fertil Steril. 2008 Nov 13. [Epub ahead of print]
Pregnancy outcome after magnetic resonance-guided focused ultrasound surgery
(MRgFUS) for conservative treatment of uterine fibroids.
Rabinovici J, David M, Fukunishi H, Morita Y, Gostout BS, Stewart EA; for the MRgFUS Study Group.
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel.
Objective
To report all pregnancies to date after magnetic resonance-guided focused ultrasound surgery (MRgFUS) for the conservative treatment of clinically significant uterine fibroids.
Design:
Prospective registry of all known pregnancies occurring after MRgFUS maintained by the device manufacturer and reported to the Food and Drug Administration.
Setting:
World experience of pregnancies after treatment with reports from 13 sites in seven countries.
Patients:
Fifty-one reproductive-age women with uterine leiomyomas.
Interventions:
Women underwent MRgFUS treatment for symptomatic uterine leiomyomas before this report.
Main Outcome Measures:
Pregnancy outcomes and complications.
Results:
Fifty-four pregnancies in 51 women have occurred after MRgFUS treatment of uterine leiomyomas. The mean time to conception was 8 months after treatment. Live births occurred in 41% of pregnancies, with a 28% spontaneous abortion rate, an 11% rate of elective pregnancy termination, and 11 (20%) ongoing pregnancies beyond 20 gestational weeks. The mean birth weight was 3.3 kg, and the vaginal delivery rate was 64%.
Conclusions:
Preliminary pregnancy experience after MRgFUS is encouraging, with a high rate of delivered and ongoing pregnancies.
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