Radiology. 2003 Mar;226(3):897-905.
MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study.
Tempany CM, Stewart EA, McDannold N, Quade BJ, Jolesz FA, Hynynen K.
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA. ctempany@bwh.harvard.edu
The feasibility and safety of magnetic resonance (MR) imaging-guided focused
ultrasound surgery for uterine leiomyomas is reported. Sequential
sonications were delivered to nine targets. Temperature-sensitive
phase-difference MR imaging monitored the location of the focus and measured
tissue temperature elevations, ensuring therapeutic dose. MR images and
hysterectomy specimens were evaluated. Six leiomyomas received full
therapeutic doses, and 98.5% of the sonications were visualized. MR
thermometry was successful in all sonications and cases. Focal necrotic
lesions were seen in all cases at MR, and five were pathologically
confirmed. MR imaging-guided focused ultrasound causes thermocoagulation and
necrosis in uterine leiomyomas and is feasible and safe, without serious
consequences.
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